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This text focuses on the algebraic formulation of quantum field theory, from the introductory aspects to the applications to concrete problems of physical interest. The book is divided in thematic chapters covering both introductory and more advanced topics. These include the algebraic, perturbative approach to interacting quantum field theories, algebraic quantum field theory on curved spacetimes (from its structural aspects to the applications in cosmology and to the role of quantum spacetimes), algebraic conformal field theory, the Kitaev's quantum double model from the point of view of local quantum physics and constructive aspects in relation to integrable models and deformation techniques.The book is addressed to master and graduate students both in mathematics and in physics, who are interested in learning the structural aspects and the applications of algebraic quantum field theory.